USING BAYESIAN METHODS IN THE TASK OF MODELING THE PATIENTS' PHARMACORESISTANCE DEVELOPMENT
Mariia A. Voronenko
Kherson National Technical University (Ukraine)
http://orcid.org/0000-0002-5392-5125
Ulzhalgas M. Zhunissova
Astana Medical University (Kazakhstan)
http://orcid.org/0000-0001-5255-9314
Saule S. Smailova
D.Serikbayev East Kazakhstan State Technical University (Kazakhstan)
http://orcid.org/0000-0002-8411-3584
Luidmila N. Lytvynenko
Kherson City Psychoneurological Clinic (Ukraine)
http://orcid.org/0000-0001-8445-5704
Nataliia B. Savina
National University of Water and Environmental Engineering (Ukraine)
http://orcid.org/0000-0001-8339-1219
Pavlo P. Mulesa
Uzhhorod National University (Ukraine)
http://orcid.org/0000-0002-3437-8082
Volodymyr I. Lytvynenko
immun56@gmail.comKherson National Technical University (Ukraine)
http://orcid.org/0000-0002-1536-5542
Abstract
In this paper, we propose a methodology for using static Bayesian networks (BN) in modeling the development of pharmacoresistance in patients with a diagnosis of epilepsy. Methods for constructing the structure of a static BN, their parametric training, validation, sensitivity analysis and “What-if” scenario analysis are considered. The model was designed in collaboration with expert doctors, as well as expert pharmacologists in the selection and quantification of input and output variables.
Keywords:
epileptology, pharmacoresistance, Bayesian networks, structural learning, parametric learning, sensitivity analysis, validationReferences
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Authors
Mariia A. VoronenkoKherson National Technical University Ukraine
http://orcid.org/0000-0002-5392-5125
Authors
Ulzhalgas M. ZhunissovaAstana Medical University Kazakhstan
http://orcid.org/0000-0001-5255-9314
Authors
Saule S. SmailovaD.Serikbayev East Kazakhstan State Technical University Kazakhstan
http://orcid.org/0000-0002-8411-3584
Authors
Luidmila N. LytvynenkoKherson City Psychoneurological Clinic Ukraine
http://orcid.org/0000-0001-8445-5704
Authors
Nataliia B. SavinaNational University of Water and Environmental Engineering Ukraine
http://orcid.org/0000-0001-8339-1219
Authors
Volodymyr I. Lytvynenkoimmun56@gmail.com
Kherson National Technical University Ukraine
http://orcid.org/0000-0002-1536-5542
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