A USAGE OF THE IMPEDANCE METHOD FOR DETECTING CIRCULATORY DISORDERS TO DETERMINE THE DEGREE OF LIMB ISCHEMIA

New engineering technologies allow the creation of diagnostic devices for predicting the development of acute tissue ischemia of the extremities and determining the residual time until the removal of the tourniquet, and solving these tasks is particularly relevant during military actions. Acute limb ischemia is a sudden critical decrease in perfusion that threatens the viability of the limb. The incidence of this condition is 1.5 cases per 10 000 people per year. Acute ischemia occurs due to the blockage of blood flow in major arteries (embolism, thrombosis, trauma), leading to the cessation of adequate blood supply to metabolically active tissues of the limb, including the skin, muscles, and nerve endings. To address these issues, the article analyzes the changes in the impedance of biological tissue. The introduction and use of the coefficient of relative electrical conductivity, denoted as k, as a diagnostic criterion parameter, are justified. Experimental studies of changes in the coefficient of relative electrical conductivity k were conducted, confirming that the transition from exponential to linear dependencies of the coefficient establishes the degree of viability of the biological cell (tissue) and the moment of occurrence of reperfusion syndrome. It has been established that a deviation of the value of k by 10–15% from its unit value diagnoses the initial process of blood perfusion impairment and the development of ischemic tissue disease. The rate of change of k serves as a criterion for predicting the progression of the disease and as a corrective factor for therapeutic treatment.

Keywords:

ischemic tissue disease, perfusion, reperfusion syndrome, tourniquet, transient process, ionization, disease progression diagnosis, forecasting

References

Bera T. K.: Bioelectrical Impedance and The Frequency Dependent Current Conduction Through Biological Tissues: A Short Review. IOP Conference Series Materials Science and Engineering 331(1), 2018, 012005. DOI: https://doi.org/10.1088/1757-899X/331/1/012005

Bera T. K.: Methods of bioelectrical impedance for non-invasive health monitoring. Review article. 2014, 381251. DOI: https://doi.org/10.1155/2014/381251

Blaisdell F. W.: The pathophysiology of skeletal muscle ischemia and the reperfusion syndrome: a review, Cardiovasc. Surg., 10(6), 2002, 620–630. DOI: https://doi.org/10.1016/S0967-2109(02)00070-4

Bosboom E. M., Hesselink M. K., Oomens C. W., Bouten C. V., Drost M. R., Baaijens F. P.: Passive transverse mechanical properties of skeletal muscle under in vivo compression. J Biomech, Oct 34(10), 2001, 1365–1368. DOI: https://doi.org/10.1016/S0021-9290(01)00083-5

Bouten C. V. C., Breuls R. G. M., Peeters E. A. G., Oomens C. W. J., Baaijens F. P. T.: In vitro models to study compressive strain-induced muscle cell damage. Biorheology 40(1–3), 2003, 383–388.

Didukh V. D.: Biological physics with physical methods of analysis: teaching. Village, Ternopil, 2021.

European Convention "On the Protection of Vertebrate Animals Used for Research and Other Scientific Purposes". Strasbourg, 1986.

Frink M., Lechler P., Debus F., Ruchholtz S.: Multiple trauma and emergency room management. Dtsch. Arztebl. Int 114(29–30), 2017, 497–503. DOI: https://doi.org/10.3238/arztebl.2017.0497

Jiang Z., Yao J., Wang L., Wu H., Huang J., Zhao T., Takei M.: Development of a portable electrochemical impedance spectroscopy system for bio-detection. IEEE Sensors Journal, 19(15), 2019, 5979–5987 [http://doi.org/10.1109/JSEN.2019.2911718]. DOI: https://doi.org/10.1109/JSEN.2019.2911718

Katelyan O. V. et al.: Study of the peripheral blood circulation of an abdominal wall using optoelectronic plethysmograph. Information Technology in Medical Diagnostics II. CRC Press, Balkema book, Taylor & Francis Group, London, 2019, 119–125. DOI: https://doi.org/10.1201/9780429057618-15

Koutsouras D. A., Lingstedt L. V., Lieberth K., Reinholz J., Mailänder V., Blom P. W. M., Gkoupidenis P.: Probing the impedance of a biological tissue with PEDOT:PSS-Coated metal electrodes: Effect of electrode size on sensing efficiency. Adv. Healthcare Mater. 8, 2019, 1901215 [http://doi.org/10.1002/adhm.201901215]. DOI: https://doi.org/10.1002/adhm.201901215

Kozlovska T. I. et al.: Device to determine the level of peripheral blood circulation and saturation. Proc. SPIE 10031, 2016, 100312Z. DOI: https://doi.org/10.1117/12.2249131

Krivonosov V. E., Pavlov S. V., Sander S. V., Martyniuk L. V.: Method of detection and control of the development of ischemia of biological tissue. Patent No. 118335, dated 11.05.2023.

Kryvonosov V., Prudnikova N., Martyniuk L.: Justification of the electrical scheme of biological tissue replacementunder the action of DC voltage. Machinery & Energetics 13(4), 2022. DOI: https://doi.org/10.31548/machenergy.13(4).2022.60-71

Law of Ukraine No. 3447-VI "On the Protection of Animals from Cruelty", October 16, 2012.

Maegele M., Spinella P., Schöchl H.: The acute coagulopathy of trauma: mechanisms and tools for risk stratification. Shock 38, 2012, 450–458. DOI: https://doi.org/10.1097/SHK.0b013e31826dbd23

Mansoorifar A., Koklu A., Shihong M., Raj G. V., Beskok A.: Electrical Impedance Measurements of Biological Cells in Response to External Stimuli. Anal. Chem. 90(7), 2018, 4320–4327. DOI: https://doi.org/10.1021/acs.analchem.7b05392

Martsenyuk V. P.: Medical and biological physics. Ukrmedknyga, Ternopil, 2012.

Naranjo-Hernández D., Reina-Tosina J., Min M.: Fundamentals, Recent Advances, and Future Challenges in Bioimpedance Devices for Healthcare Applications. 2019, 9210258 [http://doi.org/10.1155/2019/9210258]. DOI: https://doi.org/10.1155/2019/9210258

Norgren L., Hiatt W. R., Dormandy J. A., Nehler M. R., Harris K. A., Fowkes F. G.: Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II). J Vasc Surg. 45, 2007, S5-S67. DOI: https://doi.org/10.1016/j.jvs.2006.12.037

Oyeniyi B. T. et al.: Trends in 1029 trauma deaths at a level 1 trauma center. Injury 48(1), 2017, 5–12. DOI: https://doi.org/10.1016/j.injury.2016.10.037

Paradis S. et al.: Chronology of mitochondrial and cellular events during skeletal muscle ischemia-reperfusion. American Journal of Physiology. Cell Physiology, 310(11), 2016, C968–C982 [http://doi.org/10.1152/ajpcell.00356.2015]. DOI: https://doi.org/10.1152/ajpcell.00356.2015

Pavlov S. V. et al.: Analysis of microcirculatory disorders in inflammatory processes in the maxillofacial region on based of optoelectronic methods. Przeglad Elektrotechniczny 93(5), 2017, 114–117. DOI: https://doi.org/10.15199/48.2017.05.23

Pavlov S. V. et al.: Electro-optical system for the automated selection of dental implants according to their colour matching. Przeglad Elektrotechniczny 93(3), 2017, 121–124. DOI: https://doi.org/10.15199/48.2017.03.28

Prasad A., Roy M.: Bioimpedance analysis of vascular tissue and fluid flow in human and plant body: A review. Biosystems Engineering 197, 2020, 170–187. DOI: https://doi.org/10.1016/j.biosystemseng.2020.06.006

Tereshchenko N. F., Tsapenko V. V., Chuhraev N. V.: Research of electrical conductivity of biological animals. Bulletin of NTUU "KPI". Instrumentation series 53(1), 2017. DOI: https://doi.org/10.20535/1970.53(1).2017.106807

Wang G.: Holder David S: Electrical Impedance Tomography (1st edition). BioMedical Engineering OnLine 4, 2005, 27 [http://doi.org/10.1186/1475-925X-4-27]. DOI: https://doi.org/10.1186/1475-925X-4-27

Wójcik W. et al.: Medical Fuzzy-Expert System for Assessment of the Degree of Anatomical Lesion of Coronary Arteries. International Journal of Environmental Research and Public Health 20(2), 2023, 979 [http://doi.org/10.3390/ijerph20020979]. DOI: https://doi.org/10.3390/ijerph20020979

Wójcik W., Smolarz A.: Information Technology in Medical Diagnostics. CRC Press, 2017. DOI: https://doi.org/10.1201/9781315098050

Zarutskyi Y. L., Shudrak A. A.: Instructions for military field surgery. Chalchynska N. V.: Damage to the main vessels. Kyiv 2014, 351–373.

Kryvonosov, V., Avrunin, O., Sander, S., Pavlov, V., Martyniuk, L., & Zhumazhanov, B. (2023). A USAGE OF THE IMPEDANCE METHOD FOR DETECTING CIRCULATORY DISORDERS TO DETERMINE THE DEGREE OF LIMB ISCHEMIA. Informatyka, Automatyka, Pomiary W Gospodarce I Ochronie Środowiska, 13(4), 5–10. https://doi.org/10.35784/iapgos.5393

A USAGE OF THE IMPEDANCE METHOD FOR DETECTING CIRCULATORY DISORDERS TO DETERMINE THE DEGREE OF LIMB ISCHEMIA

Issue Vol. 13 No. 4 (2023)

Archives

DOI

Authors

Abstract

Keywords:

References

License

Article Sidebar

Issue Vol. 13 No. 4 (2023)

Archives

Main Article Content

DOI

Authors

Abstract

Keywords:

References

Article Details

License